Chris Sander is a computational biologist and professor of cell biology at the Dana-Farber Cancer Institute and Harvard Medical School. He previously served as chair of the Computational Biology Programme at the Memorial Sloan–Kettering Cancer Center in New York City. Sander's research focuses on solving biological problems using quantitative methods from bioinformatics, data science, statistics, computer science, and mathematics.
Sander received his undergraduate degree in physics from the University of Berlin in 1967. He then studied at the University of California, Berkeley and the Niels Bohr Institute in Copenhagen before obtaining his PhD in theoretical physics from the State University of New York in 1975. His thesis was titled "Analytic properties of bound state wave functions."
Sander's transition from theoretical physics to computational biology was influenced by Fred Sanger's landmark 1977 paper in Nature, which published the nucleotide sequence of bacteriophage φX174. Sander has contributed significantly to the field of structural bioinformatics, developing tools such as the Families of Structurally Similar Proteins (FSSP) database and the DSSP algorithm for assigning secondary structure to amino acids.
Sander founded the biocomputing program at the European Molecular Biology Laboratory in Heidelberg and later moved it to the European Bioinformatics Institute in Cambridge. He served as chief information officer for Millennium Pharmaceuticals and advised IBM's Deep Computing Initiative, which created the Deep Blue chess computer.
In 2015, Sander relocated his lab to the Dana–Farber Cancer Institute and the Cell Biology Department at Harvard Medical School. He has held editorial positions at the journal "Bioinformatics" and was honoured with the ISCB Accomplishment by a Senior Scientist Award in 2010 and the DeLano Award for Computational Biosciences in 2018.
Chris Sander is a computational biologist and professor in residence of cell biology at Harvard Medical School. He is based at the Dana-Farber Cancer Center in Boston, MA, and is also a special advisor for quantitative biology at the Ludwig Center at Harvard and an associate member of the Broad Institute at Harvard and MIT.
Sander originally trained as a physicist, receiving his undergraduate degree from the University of Berlin in 1967. He then studied at the University of California, Berkeley, and the Niels Bohr Institute in Copenhagen before gaining his PhD in theoretical physics from the State University of New York in 1975. His thesis was titled "Analytic properties of bound state wave functions".
Sander moved from theoretical physics to computational biology following Fred Sanger's landmark 1977 paper in Nature, in which the nucleotide sequence of bacteriophage φX174 was published. He has since made significant contributions to the field of structural bioinformatics, including developing tools such as the Families of Structurally Similar Proteins (FSSP) database and the DSSP algorithm, which assigns secondary structure to amino acids.
Sander founded the biocomputing program at the European Molecular Biology Laboratory in Heidelberg and later moved the program to the European Bioinformatics Institute in Cambridge, where he served as co-founder. He has also held positions at the Memorial Sloan-Kettering Cancer Center in New York City, where he was chair of the Computational Biology Programme, and at Millennium Pharmaceuticals, where he served as chief information officer. In 2015, he moved his lab to the Dana-Farber Cancer Institute and the Cell Biology Department at Harvard Medical School.
Sander has been recognised for his research, receiving the ISCB Accomplishment by a Senior Scientist Award in 2010 and the 2018 DeLano Award for Computational Biosciences. He has also been involved in editorial roles, serving as Executive Editor for the journal Bioinformatics and, in 2014, being appointed one of its first Honorary Editors.
Sander's research focuses on solving biological problems using quantitative methods from various disciplines, including bioinformatics, data science, statistics, computer science, and mathematics. His lab applies computational methods to build predictive network models of molecular and cell-cell interactions, supporting cancer precision medicine and making discoveries in structural and evolutionary biology. They have a particular interest in combining experimental and computational systems biology approaches to identify drug combinations that can overcome drug resistance.
Sander and his team have collaborated with clinicians at the Dana-Farber Cancer Institute and Memorial Sloan Kettering to apply bioinformatics analysis to cancer genomics. They are also working on projects related to evolutionary biology, structural biology, and cell biology, such as generating evolutionarily constrained sequences and developing a quantitative theory linking biopolymer sequences to phenotypic outcomes.
Chris Sander
Harvard Medical School, Broad Institute, Dana-Farber Cancer Institute, Memorial Sloan Kettering
http://bit.ly/tob48p
Dictionary of protein secondary structure: pattern recognition of hydrogen‐bonded and geometrical features W Kabsch, C Sander Biopolymers: Original Research on Biomolecules 22 (12), 2577-2637, 1983 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=4R7wW8AAAAJ&citationforview=4R7wW8AAAAJ:4hFrxpcac9AC
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data E Cerami, J Gao, U Dogrusoz, BE Gross, SO Sumer, BA Aksoy, … Cancer discovery 2 (5), 401-404, 2012 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=4R7wW8AAAAJ&citationforview=4R7wW8AAAAJ:ijdKiLOsEJMC
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal J Gao, BA Aksoy, U Dogrusoz, G Dresdner, B Gross, SO Sumer, Y Sun, … Science signaling 6 (269), pl1-pl1, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=4R7wW8AAAAJ&citationforview=4R7wW8AAAAJ:nRpfm8aw39MC
Comprehensive molecular portraits of human breast tumours Brigham & Women’s Hospital & Harvard Medical School Chin Lynda 9 11 Park … Nature 490 (7418), 61-70, 2012 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=4R7wW8AAAAJ&citationforview=4R7wW8AAAAJ:In6cVmBjs0IC
Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer NA Rizvi, MD Hellmann, A Snyder, P Kvistborg, V Makarov, JJ Havel, … Science 348 (6230), 124-128, 2015 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=4R7wW8AAAAJ&citationforview=4R7wW8AAAAJ:LK8CI43ZvvMC
Comprehensive molecular characterization of human colon and rectal cancer Cancer Genome Atlas Network Nature 487 (7407), 330, 2012 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=4R7wW8AAAAJ&citationforview=4R7wW8AAAAJ:NyGDZy8z5eUC
Comprehensive genomic characterization defines human glioblastoma genes and core pathways Cancer Genome Atlas Research Network Tissue source sites: Duke University … Nature 455 (7216), 1061-1068, 2008 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=4R7wW8AAAAJ&citationforview=4R7wW8AAAAJ:4X0JR2_MtJMC
Integrated genomic analyses of ovarian carcinoma Cancer Genome Atlas Research Network Nature 474 (7353), 609, 2011 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=4R7wW8AAAAJ&citationforview=4R7wW8AAAAJ:AvfA0Oy_GE0C
The cancer genome atlas pan-cancer analysis project JN Weinstein, EA Collisson, GB Mills, KR Shaw, BA Ozenberger, K Ellrott, … Nature genetics 45 (10), 1113-1120, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=4R7wW8AAAAJ&citationforview=4R7wW8AAAAJ:W1ZWpF0a3GIC
Comprehensive molecular characterization of gastric adenocarcinoma Cancer Genome Atlas Research Network Nature 513 (7517), 202, 2014 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=4R7wW8AAAAJ&citationforview=4R7wW8AAAAJ:SpPTWFSNUtQC
The somatic genomic landscape of glioblastoma CW Brennan, RGW Verhaak, A McKenna, B Campos, H Noushmehr, … cell 155 (2), 462-477, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=4R7wW8AAAAJ&citationforview=4R7wW8AAAAJ:mKu_rENv82IC
Integrated genomic characterization of endometrial carcinoma DA Levine, … Nature 497 (7447), 67-73, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=4R7wW8AAAAJ&citationforview=4R7wW8AAAAJ:xyzrkeHX5M4C
Protein structure comparison by alignment of distance matrices L Holm, C Sander Journal of molecular biology 233 (1), 123-138, 1993 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=4R7wW8AAAAJ&citationforview=4R7wW8AAAAJ:u5HHmVD_uO8C
The immune landscape of cancer V Thorsson, DL Gibbs, SD Brown, D Wolf, DS Bortone, THO Yang, … Immunity 48 (4), 812-830. e14, 2018 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=4R7wW8AAAAJ&citationforview=4R7wW8AAAAJ:ShjGdcaqzI0C
Human microRNA targets B John, AJ Enright, A Aravin, T Tuschl, C Sander, DS Marks PLoS biology 2 (11), e363, 2004 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=4R7wW8AAAAJ&citationforview=4R7wW8AAAAJ:IjCSPb-OGe4C
A mammalian microRNA expression atlas based on small RNA library sequencing P Landgraf, M Rusu, R Sheridan, A Sewer, N Iovino, A Aravin, S Pfeffer, … Cell 129 (7), 1401-1414, 2007 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=4R7wW8AAAAJ&citationforview=4R7wW8AAAAJ:ZzlSgRqYykMC
Integrative genomic profiling of human prostate cancer BS Taylor, N Schultz, H Hieronymus, A Gopalan, Y Xiao, BS Carver, … Cancer cell 18 (1), 11-22, 2010 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=4R7wW8AAAAJ&citationforview=4R7wW8AAAAJ:jL-93Qbq4QoC
Prediction of protein secondary structure at better than 70% accuracy B Rost, C Sander Journal of molecular biology 232 (2), 584-599, 1993 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=4R7wW8AAAAJ&citationforview=4R7wW8AAAAJ:u-x6o8ySG0sC
MicroRNA Targets in Drosophila A Enright, B John, U Gaul, T Tuschl, C Sander, D Marks Genome biology 4, 1-27, 2003 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=4R7wW8AAAAJ&citationforview=4R7wW8AAAAJ:Y0pCki6q_DkC
Comprehensive genomic characterization of squamous cell lung cancers Cancer Genome Atlas Research Network Nature 489 (7417), 519, 2012 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=4R7wW8AAAAJ&citationforview=4R7wW8AAAAJ:1lhNe0rCu4AC
Debora Marks googlescholarauthorid deboramarks.md:qFmoeNkAAAAJ
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Anders Jacobsen Skanderup googlescholarauthorid andersjacobsen_skanderup.md:r06O54MAAAAJ
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Summary: Chris Sander may refer to:
Chris Sander (footballer) (born 1962), Welsh footballer Chris Sander (scientist), computational biologist Chris Sander (Missouri politician), member of the Missouri House of Representatives from the 33rd district
URL: https://en.wikipedia.org/wiki/Chris_Sander
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Content: Chris Sander may refer to:
Chris Sander (footballer) (born 1962), Welsh footballer Chris Sander (scientist), computational biologist Chris Sander (Missouri politician), member of the Missouri House of Representatives from the 33rd district
Youtube Title: Chris Sander: DeLano Award for Computational Biosciences
Youtube Link: link
Youtube Channel Name: American Society for Biochemistry and Molecular Biology (ASBMB)
Youtube Channel Link: https://www.youtube.com/@asbmb
Chris Sander: DeLano Award for Computational Biosciences
Youtube Title: Chris Sander on staying focused
Youtube Link: link
Youtube Channel Name: American Society for Biochemistry and Molecular Biology (ASBMB)
Youtube Channel Link: https://www.youtube.com/@asbmb
Chris Sander on staying focused
Youtube Title: AI Meets Bio with Chris Sander, Brian Vandahl, & Joshua Dunn (mod. Claire Evans) #GinkgoFerment 2023
Youtube Link: link
Youtube Channel Name: Ginkgo Bioworks
Youtube Channel Link: https://www.youtube.com/@ginkgobioworks9749
AI Meets Bio with Chris Sander, Brian Vandahl, & Joshua Dunn (mod. Claire Evans) #GinkgoFerment 2023
Youtube Title: PDB50 at the ACA: Chris Sander, Harvard Medical School
Youtube Link: link
Youtube Channel Name: RCSBProteinDataBank
Youtube Channel Link: https://www.youtube.com/@RCSBProteinDataBank
PDB50 at the ACA: Chris Sander, Harvard Medical School
Youtube Title: Chris Sander Discusses Precision Combination Therapy
Youtube Link: link
Youtube Channel Name: Cambridge Innovation Institute
Youtube Channel Link: https://www.youtube.com/@CambridgeHealthtech
Chris Sander Discusses Precision Combination Therapy
Youtube Title: Chris Sanders (Stitch) and David Ogden Stiers (Jumba) Recording for “Lilo & Stitch”
Youtube Link: link
Youtube Channel Name: Chris Sanders Art
Youtube Channel Link: https://www.youtube.com/@ChrisSandersArt
Chris Sanders (Stitch) and David Ogden Stiers (Jumba) Recording for “Lilo & Stitch”
Youtube Title: #20 – Chris Sander: Mapping the Labyrinth
Youtube Link: link
Youtube Channel Name: Einstein Foundation Berlin
Youtube Channel Link: https://www.youtube.com/@EinsteinFoundationBerlin
#20 – Chris Sander: Mapping the Labyrinth
Youtube Title: Rep. Chris Sander decries bills restricting gender affirming care and transgender athletes
Youtube Link: link
Youtube Channel Name: Jason Rosenbaum
Youtube Channel Link: https://www.youtube.com/@jasonrosenbaum
Rep. Chris Sander decries bills restricting gender affirming care and transgender athletes
Youtube Title: Chris Sander (scientist) | Wikipedia audio article
Youtube Link: link
Youtube Channel Name: Subhajit Sahu
Youtube Channel Link: https://www.youtube.com/@wolfram77
Chris Sander (scientist) | Wikipedia audio article
Youtube Title: Chris Sanders' Spine-Chilling Spoon Collection Story | Trick or Tales
Youtube Link: link
Youtube Channel Name: Bobby Chiu
Youtube Channel Link: https://www.youtube.com/@BobbyChiu
Chris Sanders' Spine-Chilling Spoon Collection Story | Trick or Tales
Youtube Title: Chris Stapleton’s “Either Way” cover by Heath Sanders
Youtube Link: link
Youtube Channel Name: Heath Sanders
Youtube Channel Link: https://www.youtube.com/channel/UCelv297kFbI8b1ki6hPFxrg
Chris Stapleton’s “Either Way” cover by Heath Sanders
Youtube Title: Westran Boys Basketball With Head Coach Chris Sander
Youtube Link: link
Youtube Channel Name: Missouri Sports Network
Youtube Channel Link: https://www.youtube.com/@missourisportsnetwork3668
Westran Boys Basketball With Head Coach Chris Sander
Youtube Title: Lou Sanders gags at a shocking dog story | The Chris and Rosie Ramsey Show - BBC
Youtube Link: link
Youtube Channel Name: BBC
Youtube Channel Link: https://www.youtube.com/@BBC
Lou Sanders gags at a shocking dog story | The Chris and Rosie Ramsey Show - BBC
Youtube Title: Westran Hornet Head Basketball Coach Chris Sander
Youtube Link: link
Youtube Channel Name: Missouri Sports Network
Youtube Channel Link: https://www.youtube.com/@missourisportsnetwork3668
Westran Hornet Head Basketball Coach Chris Sander
Youtube Title: Chris Sander
Youtube Link: link
Youtube Channel Name: Hill Country Honda Sales Team
Youtube Channel Link: https://www.youtube.com/@hillcountryhondasalesteam4736
Chris Sander
Youtube Title: SMALP-Journal Club #15. Chris Sander, University of California, Irvine.
Youtube Link: link
Youtube Channel Name: SMALP- Journal Club
Youtube Channel Link: https://www.youtube.com/@smalp-journalclub8613
SMALP-Journal Club #15. Chris Sander, University of California, Irvine.
Youtube Title: Rose-Hulman Football Week 5 HCAC Def POTW - Chris Sander
Youtube Link: link
Youtube Channel Name: RHIT Football
Youtube Channel Link: https://www.youtube.com/@RoseHulmanFootball
Rose-Hulman Football Week 5 HCAC Def POTW - Chris Sander
Youtube Title: Chris Sander and Russ Carnahan Debate for Congress Third District (Missouri) 8
Youtube Link: link
Youtube Channel Name: anchorstlseo
Youtube Channel Link: https://www.youtube.com/@anchorstlseo
Chris Sander and Russ Carnahan Debate for Congress Third District (Missouri) 8