doi.bio/edouard_de_castro

Edouard De Castro

Overview

Edouard De Castro is a scientist and software developer with a Ph.D. in Biochemistry from the University of Geneva, Switzerland. He currently works as a senior software developer at the Swiss Institute of Bioinformatics, where he has been since 2002. De Castro's research interests include functional and concurrent programming, full-stack development, and data visualization. He has also worked as a research scientist at the University of Colorado at Boulder and the University of Geneva, and has experience in the video game industry as a freelance game developer.

Education

1992: Master's in Biochemistry, University of Geneva, Switzerland
1993: Research assistant, University of Geneva, Switzerland
1997: Ph.D. in Biochemistry, University of Geneva, Switzerland

Work Experience

1988-1989: Sold a game to Ubisoft Entertainment as a freelance software developer/game developer
1992: Software developer/research assistant, University of Geneva, Switzerland
1997-1998: Research Scientist (molecular neurobiology), University of Geneva, Switzerland
1998-2002: Research Scientist (molecular biology of aging), University of Colorado at Boulder, USA
2002-present: Senior software developer, Swiss Institute of Bioinformatics, Switzerland

Publications

De Castro has numerous publications in the fields of biochemistry, molecular biology, and bioinformatics. Notable publications include:

1995: "Regulation of rhodopsin phosphorylation by a family of neuronal calcium sensors"
1996: "Direct modulation of calmodulin targets by the neuronal calcium sensor NCS-1"
2001: "Ca2+-Signaling via the Neuronal Calcium Sensor-1 Regulates Associative Learning and Memory in C. elegans"
2004: "Isolation of long-lived mutants in Caenorhabditis elegans using juglone resistance selection"
2005: "ProRule: a new database containing functional and structural information on PROSITE profiles"
2006: "The PROSITE database" and "ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins"
2008: "The 20 years of PROSITE"
2009: "HAMAP: a database of completely sequenced microbial proteome sets and manually curated microbial protein families in UniProtKB/Swiss-Prot"
2010: "PROSITE, a protein domain database for functional characterization and annotation" and "ViralZone: a knowledge resource to understand virus diversity"
2011: "SwissBioPics - an interactive library of cell images for the visualization of subcellular location data"
2012: "ExPASy: SIB bioinformatics resource portal"
2013: "New and continuing developments at PROSITE" and "ViralZone: recent updates to the virus knowledge resource"
2015: "HAMAP in 2015: updates to the protein family classification and annotation system"

- 2019-2022: Various publications on UniProt, SwissBioPics, and other related topics

Edouard De Castro

Edouard De Castro is a researcher in the field of biochemistry and genomics. He has contributed to numerous publications in these fields, with a particular focus on protein knowledgebases and virus knowledge resources.

Education and Career

Currently, there is no available information regarding De Castro's early life, educational background, or current employment. However, his extensive list of publications indicates a career in research.

Publications

De Castro has authored or co-authored several articles in renowned journals, including:

2004: "Recent improvements to the PROSITE database" in the Nucleic Acids Res. journal. This article focuses on enhancements made to the PROSITE database, a resource for protein domain information.
2005: "ProRule: a new database containing functional and structural information on PROSITE profiles" in the Bioinformatics journal. This work introduced a new database, ProRule, which provides insights into PROSITE profiles and their applications.
2006: "The PROSITE database" and "ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins" in the Nucleic Acids Res. journal. The former article offers an overview of the PROSITE database, while the latter discusses ScanProsite, a tool for identifying PROSITE signature matches.
2008: "The 20 years of PROSITE" in the Nucleic Acids Res. journal. This publication commemorates two decades of the PROSITE database and its contributions to protein research.
2009: "HAMAP: a database of completely sequenced microbial proteome sets and manually curated microbial protein families in UniProtKB/Swiss-Prot" in the Nucleic Acids Res. journal. This article introduces the HAMAP database, which provides information on completely sequenced microbial proteomes and protein families.
2010: "PROSITE, a protein domain database for functional characterization and annotation" in the Nucleic Acids Res. journal. This work highlights PROSITE as a valuable resource for functional characterization and annotation of protein domains.
2011: "ViralZone: a knowledge resource to understand virus diversity" in the Nucleic Acids Res. journal. This article presents ViralZone, a knowledgebase designed to enhance understanding of virus diversity.
2012: "ExPASy: SIB bioinformatics resource portal" in the Nucleic Acids Res. journal. This publication introduces the ExPASy portal, a bioinformatics resource developed by the SIB Swiss Institute of Bioinformatics.
2013: "New and continuing developments at PROSITE" and "ViralZone: recent updates to the virus knowledge resource" in the Nucleic Acids Res. journal. The former article discusses ongoing advancements in the PROSITE database, while the latter highlights updates to the ViralZone resource.
2015: "HAMAP in 2013, new developments in the protein family classification and annotation system" and "HAMAP in 2015: updates to the protein family classification and annotation system" in the Nucleic Acids Res. journal. These articles provide updates on the HAMAP database, including new developments and enhancements.
2020: "Enzyme annotation in UniProtKB using Rhea" in the Bioinformatics journal. This work focuses on enzyme annotation using the Rhea database in UniProtKB.
2021: "SwissBioPics - an interactive library of cell images for the visualization of subcellular location data" in the Database J. Biol. Databases Curation journal. This article introduces SwissBioPics, an interactive library of cell images for subcellular data visualization.
2021: "UniRule: a unified rule resource for automatic annotation in the UniProt Knowledgebase" and "UniProt: the universal protein knowledgebase in 2021" in the Bioinformatics and Nucleic Acids Res. journals, respectively. The first article introduces UniRule, a tool for automatic annotation, while the second provides an overview of the UniProt Knowledgebase.

De Castro's research has been widely recognized and cited, with his publications appearing in prominent journals in the fields of biochemistry and genomics. His work has contributed significantly to the understanding and advancement of protein knowledgebases, virus knowledge resources, and bioinformatics tools.