doi.bio/frank_j_poelwijk
Frank J. Poelwijk
Overview
Frank J. Poelwijk is a researcher in the field of biochemistry and genomics, with a focus on machine learning and AI techniques. He currently works at the Dana-Farber Cancer Institute in Boston, USA, and has previously held positions at the University of Texas Southwestern Medical Center and the University of Amsterdam. Poelwijk's research interests include evolutionary biology, protein structure and function, and the application of machine learning to biological systems.
Education and Career
Poelwijk obtained his PhD from the University of Amsterdam, where he worked on understanding the context-dependence of mutations and the significance of epistasis in biological systems. After completing his PhD, he joined the University of Texas Southwestern Medical Center as a postdoctoral researcher. In 2016, he moved to the Dana-Farber Cancer Institute, where he continues to work as a researcher.
Research Contributions and Publications
Poelwijk has made significant contributions to the field of evolutionary biology, particularly in understanding the role of epistasis in protein evolution. He has published several articles in prestigious journals such as PLoS Comput. Biol. and Nature Communications. Some of his notable works include:
- The Context-Dependence of Mutations: A Linkage of Formalisms (2016): In this article, Poelwijk and his colleagues propose a framework for understanding the context-dependence of mutations by linking different formalisms. They introduce the concept of "epistasis", which refers to the non-independence of mutation effects, and explore its implications for relating genotype to phenotype.
- Learning the pattern of epistasis linking genotype and phenotype in a protein (2019): In this Nature Communications article, Poelwijk and his team investigate the pattern of epistasis, which is critical for understanding protein evolution. They conduct a comprehensive experimental study on 213 mutants of a fluorescent protein and discover a large number of high-order epistatic interactions. They also demonstrate the sparsity of epistasis, which enables novel computational strategies for predicting phenotypes.
- Optimality and evolution of transcriptionally regulated gene expression (2011): Poelwijk and colleagues explore the evolution of transcriptionally regulated gene expression. They find that gene regulation systems evolve towards optimal regulatory responses when challenged with variable environments.
- Evolutionary Potential of a Duplicated Repressor-Operator Pair: Simulating Pathways Using Mutation Data (2006): In this PLoS Comput. Biol. article, Poelwijk and co-authors use simulation techniques to study the evolutionary potential of a duplicated repressor-operator pair. They demonstrate the importance of duplication events and the subsequent divergence process in evolutionary biology.
Awards and Recognition
Poelwijk's research has been recognised by various organisations, and he has received several awards for his contributions to the field. He was also listed as a co-inventor on multiple patent applications related to his research.
Frank J. Poelwijk
Overview
Frank J. Poelwijk is a researcher in the fields of machine learning, biochemistry, and genomics. He currently works as a scientist/engineer at Generate Biomedicines, a company pioneering the field of generative biology for drug development.
Education and Career
Poelwijk previously held positions at the Dana-Farber Cancer Institute, University of Texas Southwestern Medical Center, and the Green Center for Systems Biology. He has also been affiliated with the University of Twente and Wageningen University & Research.
Research and Publications
Poelwijk's research interests include evolutionary biology, protein structure and function, gene regulation, and the application of machine learning in these areas. His notable publications include:
- "The Context-Dependence of Mutations: A Linkage of Formalisms" (2016)
- "Optimality and evolution of transcriptionally regulated gene expression" (2011)
- "Evolutionary Potential of a Duplicated Repressor-Operator Pair: Simulating Pathways Using Mutation Data" (2006)
- "Illuminating protein space with a programmable generative model" (published in Nature)
Awards and Recognition
Poelwijk's work has been recognised by CNBC, and Generate Biomedicines was listed as one of the top 100 private deep tech companies in the world by XPRIZE Bessemer Venture Partners in 2023.
Youtube Videos
Youtube Title: Frankie hi-nrg mc - Quelli Che Benpensano (videoclip)
Youtube Link: link
Youtube Channel Name: frankiehinrgVEVO
Youtube Channel Link: https://www.youtube.com/@frankiehinrgVEVO
Frankie hi-nrg mc - Quelli Che Benpensano (videoclip)
Youtube Title: Frankie J - Obsesion (No Es Amor) (English Video Version)
Youtube Link: link
Youtube Channel Name: therealfrankiej1
Youtube Channel Link: https://www.youtube.com/channel/UC0_EyPMD1G7ET5wygqe1n8g
Frankie J - Obsesion (No Es Amor) (English Video Version)
Youtube Title: Still
Youtube Link: link
Youtube Channel Name: therealfrankiej1
Youtube Channel Link: https://www.youtube.com/channel/UC0_EyPMD1G7ET5wygqe1n8g
Still
Youtube Title: Frankie J - Don't Wanna Try (English Version)
Youtube Link: link
Youtube Channel Name: therealfrankiej1
Youtube Channel Link: https://www.youtube.com/channel/UC0_EyPMD1G7ET5wygqe1n8g
Frankie J - Don't Wanna Try (English Version)
Youtube Title: Frankie J- Obsession ft baby bash
Youtube Link: link
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Frankie J- Obsession ft baby bash
Youtube Title: I Don't Wanna Try No More - Frankie J (Lyrics)
Youtube Link: link
Youtube Channel Name: Calvin
Youtube Channel Link: https://www.youtube.com/@Ta1nt3dx
I Don't Wanna Try No More - Frankie J (Lyrics)
Youtube Title: Frank J - Extinction Vol 2 ( Edition 2021 )
Youtube Link: link
Youtube Channel Name: Moombah Records
Youtube Channel Link: https://www.youtube.com/@Moombah.Records
Frank J - Extinction Vol 2 ( Edition 2021 )
Youtube Title: Frankie J and Baby Bash "Obsession" Lyrics
Youtube Link: link
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Youtube Channel Link: https://www.youtube.com/@lavrom3
Frankie J and Baby Bash "Obsession" Lyrics
Youtube Title: Louie TheSinger x Frankie J - “Mine Are Too” (Exclusive)
Youtube Link: link
Youtube Channel Name: Louie TheSinger
Youtube Channel Link: https://www.youtube.com/channel/UCsWVtllcFWgaMMybOVUyw
Louie TheSinger x Frankie J - “Mine Are Too” (Exclusive)
Youtube Title: Frankie J - I Promise You
Youtube Link: link
Youtube Channel Name: therealfrankiej1
Youtube Channel Link: https://www.youtube.com/channel/UC0_EyPMD1G7ET5wygqe1n8g
Frankie J - I Promise You
Youtube Title: Frankie J - How To Deal
Youtube Link: link
Youtube Channel Name: therealfrankiej1
Youtube Channel Link: https://www.youtube.com/channel/UC0_EyPMD1G7ET5wygqe1n8g
Frankie J - How To Deal
Youtube Title: J Frank Video Mix #linglivejimmyfrank
Youtube Link: link
Youtube Channel Name: Dj Willie Bee
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J Frank Video Mix #linglivejimmyfrank
Youtube Title: Frankie J - No Te Quiero Ver Con Él
Youtube Link: link
Youtube Channel Name: therealfrankiej1
Youtube Channel Link: https://www.youtube.com/channel/UC0_EyPMD1G7ET5wygqe1n8g
Frankie J - No Te Quiero Ver Con Él
Youtube Title: Chiccoman Ravanne Tambour Random x Frank J Refix 2017
Youtube Link: link
Youtube Channel Name: Dj Random
Youtube Channel Link: https://www.youtube.com/@djrandom3174
Chiccoman Ravanne Tambour Random x Frank J Refix 2017
Youtube Title: Obsesion (No Es Amor) (Spanish Version)
Youtube Link: link
Youtube Channel Name: therealfrankiej1
Youtube Channel Link: https://www.youtube.com/channel/UC0_EyPMD1G7ET5wygqe1n8g
Obsesion (No Es Amor) (Spanish Version)
Youtube Title: INNA & Erik - Ruleta(Frank J Remix)
Youtube Link: link
Youtube Channel Name: qesSUPRAAA
Youtube Channel Link: https://www.youtube.com/@qessupraaa1066
INNA & Erik - Ruleta(Frank J Remix)
Youtube Title: Frankie J - More Than Words (Video - English)
Youtube Link: link
Youtube Channel Name: therealfrankiej1
Youtube Channel Link: https://www.youtube.com/channel/UC0_EyPMD1G7ET5wygqe1n8g
Frankie J - More Than Words (Video - English)
Youtube Title: Still - Frankie J
Youtube Link: link
Youtube Channel Name: aiyen26
Youtube Channel Link: https://www.youtube.com/@aiyen26
Still - Frankie J
Youtube Title: Frank J - Ey Tamam Sa (Audio 2021)
Youtube Link: link
Youtube Channel Name: Moombah Records
Youtube Channel Link: https://www.youtube.com/@Moombah.Records
Frank J - Ey Tamam Sa (Audio 2021)