doi.bio/george_m_church


George M Church

Early Life and Education

George McDonald Church was born on 28 August 1954 on MacDill Air Force Base in Tampa, Florida. He grew up in nearby Clearwater, Florida, and attended the preparatory boarding school Phillips Academy in Andover, Massachusetts, from 1968 to 1972. He then attended Duke University, obtaining a B.S. degree in zoology and chemistry in two years.

In 1973, Church began research work at Duke University with assistant professor of biochemistry Sung-Hou Kim. The following year, he started a graduate biochemistry programme at Duke on an NSF fellowship.

Career

In 1977, Church returned to graduate work at Harvard University under Walter Gilbert, completing a Ph.D. in biochemistry and molecular biology in 1984. After graduating, Church spent six months at Biogen, where Gilbert had relocated a sizable part of his former Harvard group. He then took up a Life Sciences Research Foundation postdoctoral fellowship at the University of California, San Francisco, with Gail R. Martin.

In 1986, Church joined the Harvard Medical School faculty as an assistant professor. He is now the Robert Winthrop Professor of Genetics at Harvard Medical School and a member of the Harvard-MIT health sciences and technology faculty. He was also a founding member of the Wyss Institute for Biologically Inspired Engineering at Harvard University.

Church has served as director of the Center on Bioenergy Technology at Harvard and of the Center of Excellence in Genomic Science (CEGS) at Harvard. He co-founded Veritas Genetics and its European and Latin American subsidiary, Veritas Intercontinental. In 2017, he co-founded Nebula Genomics, a personal genomics company, and in 2021, he co-founded HLTH.network, a healthcare blockchain startup.

Research

Church's research has focused on genomics, synthetic biology, and gene therapy. He has co-founded around 50 biotech companies, including Veritas Genetics, Warp Drive Bio, Knome, and Gen9 Bio. He helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. He is also known for his work on the woolly mammoth revival project and his involvement with Colossal Biosciences.

Awards and Honours

Church has received numerous awards and honours, including:

Publications

Church has authored or co-authored numerous publications, including:

Google Scholar Profile

George M Church)

Google Scholar

George Church Harvard Medical School http://arep.med.harvard.edu/ RNA-guided human genome engineering via Cas9 P Mali, L Yang, KM Esvelt, J Aach, M Guell, JE DiCarlo, JE Norville, … Science 339 (6121), 823-826, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:IjCSPb-OGe4C Cited by: 11531

Genomic sequencing. GM Church, W Gilbert Proceedings of the National Academy of Sciences 81 (7), 1991-1995, 1984 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:u5HHmVD_uO8C Cited by: 10442

Systematic determination of genetic network architecture S Tavazoie, JD Hughes, MJ Campbell, RJ Cho, GM Church Nature genetics 22 (3), 281-285, 1999 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:u-x6o8ySG0sC Cited by: 3266

Biclustering of expression data. Y Cheng, GM Church Ismb 8 (2000), 93-103, 2000 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:d1gkVwhDpl0C Cited by: 3139

The ENCODE (ENCyclopedia of DNA elements) project EA Feingold, PJ Good, MS Guyer, S Kamholz, L Liefer, K Wetterstrand, … Science 306 (5696), 636-640, 2004 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:KR6TXPE-FHQC Cited by: 2390

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering P Mali, J Aach, PB Stranges, KM Esvelt, M Moosburner, S Kosuri, L Yang, … Nature biotechnology 31 (9), 833-838, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:k_IJM867U9cC Cited by: 2281

A logic-gated nanorobot for targeted transport of molecular payloads SM Douglas, I Bachelet, GM Church Science 335 (6070), 831-834, 2012 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:kcbZDykSQC Cited by: 2270

Accurate multiplex polony sequencing of an evolved bacterial genome J Shendure, GJ Porreca, NB Reppas, X Lin, JP McCutcheon, … Science 309 (5741), 1728-1732, 2005 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:qjMakFHDy7sC Cited by: 2232

Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems JE DiCarlo, JE Norville, P Mali, X Rios, J Aach, GM Church Nucleic acids research 41 (7), 4336-4343, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:J_g5lzvAfSwC Cited by: 2022

Programming cells by multiplex genome engineering and accelerated evolution HH Wang, FJ Isaacs, PA Carr, ZZ Sun, G Xu, CR Forest, GM Church Nature 460 (7257), 894-898, 2009 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:hqOjcs7Dif8C Cited by: 1832

A deep learning approach to antibiotic discovery JM Stokes, K Yang, K Swanson, W Jin, A Cubillos-Ruiz, NM Donghia, … Cell 180 (4), 688-702. e13, 2020 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:pZ2CosqRuhkC Cited by: 1791

Multiplex and homologous recombination–mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9 JF Li, JE Norville, J Aach, M McCormack, D Zhang, J Bush, GM Church, … Nature biotechnology 31 (8), 688-691, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:1sJd4Hv_s6UC Cited by: 1772

Cas9 as a versatile tool for engineering biology P Mali, KM Esvelt, GM Church Nature methods 10 (10), 957-963, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:ZHo1McVdvXMC Cited by: 1727

Analysis of optimality in natural and perturbed metabolic networks D Segre, D Vitkup, GM Church Proceedings of the national academy of sciences 99 (23), 15112-15117, 2002 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:zYLM7Y9cAGgC Cited by: 1648

Assessing computational tools for the discovery of transcription factor binding sites M Tompa, N Li, TL Bailey, GM Church, B De Moor, E Eskin, AV Favorov, … Nature biotechnology 23 (1), 137-144, 2005 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:9yKSN-GCB0IC Cited by: 1608

Highly efficient Cas9-mediated transcriptional programming A Chavez, J Scheiman, S Vora, BW Pruitt, M Tuttle, E PR Iyer, S Lin, … Nature methods 12 (4), 326-328, 2015 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:1tZ8xJnm2c8C Cited by: 1587

Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays R Drmanac, AB Sparks, MJ Callow, AL Halpern, NL Burns, BG Kermani, … Science 327 (5961), 78-81, 2010 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:ufrVoPGSRksC Cited by: 1555

Next-generation digital information storage in DNA GM Church, Y Gao, S Kosuri Science 337 (6102), 1628-1628, 2012 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:UxriW0iASnsC Cited by: 1449

Rapid prototyping of 3D DNA-origami shapes with caDNAno SM Douglas, AH Marblestone, S Teerapittayanon, A Vazquez, GM Church, … Nucleic acids research 37 (15), 5001-5006, 2009 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:O3NaXMp0MMsC Cited by: 1363

Computational identification of cis-regulatory elements associated with groups of functionally related genes in Saccharomyces cerevisiae JD Hughes, PW Estep, S Tavazoie, GM Church Journal of molecular biology 296 (5), 1205-1214, 2000 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:2osOgNQ5qMEC Cited by: 1351

Co-authors

Luhan Yang RAPhZskAAAAJ

Kevin Esvelt eJ9qDHMAAAAJ

Prashant Mali blY0ilIAAAAJ

Marc Güell VKWCESQAAAAJ

Jay Shendure Gb8qVzQAAAAJ

Evan R. Daugharthy o_xIYNUAAAAJ

Marc Joseph Lajoie chKQSZUAAAAJ

Alejandro Chavez sbYrDlMAAAAJ

Sriram Kosuri ev8hXyEAAAAJ

James E. DiCarlo rPc3yK4AAAAJ

Harris H. Wang RFmkZ-EAAAAJ

James J Collins te5DjPQAAAAJ

Morten O A Sommer r2ZoOsMAAAAJ

Francois Vigneault MBVGFIsAAAAJ

Adam H Marblestone pRTuNPsAAAAJ

Daniel B. Goodman j1Zl4AAAAJ

Reza Kalhor aynAoP8AAAAJ

Ed Boyden q2rHA5QAAAAJ

Kun Zhang CYeurYgAAAAJ

Benjamin W Pruitt kAoP9jUAAAAJ

Google Scholar

George Church Harvard Medical School http://arep.med.harvard.edu/ RNA-guided human genome engineering via Cas9 P Mali, L Yang, KM Esvelt, J Aach, M Guell, JE DiCarlo, JE Norville, … Science 339 (6121), 823-826, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:IjCSPb-OGe4C Cited by: 11531

Genomic sequencing. GM Church, W Gilbert Proceedings of the National Academy of Sciences 81 (7), 1991-1995, 1984 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:u5HHmVD_uO8C Cited by: 10442

Systematic determination of genetic network architecture S Tavazoie, JD Hughes, MJ Campbell, RJ Cho, GM Church Nature genetics 22 (3), 281-285, 1999 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:u-x6o8ySG0sC Cited by: 3266

Biclustering of expression data. Y Cheng, GM Church Ismb 8 (2000), 93-103, 2000 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:d1gkVwhDpl0C Cited by: 3139

The ENCODE (ENCyclopedia of DNA elements) project EA Feingold, PJ Good, MS Guyer, S Kamholz, L Liefer, K Wetterstrand, … Science 306 (5696), 636-640, 2004 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:KR6TXPE-FHQC Cited by: 2390

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering P Mali, J Aach, PB Stranges, KM Esvelt, M Moosburner, S Kosuri, L Yang, … Nature biotechnology 31 (9), 833-838, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:k_IJM867U9cC Cited by: 2281

A logic-gated nanorobot for targeted transport of molecular payloads SM Douglas, I Bachelet, GM Church Science 335 (6070), 831-834, 2012 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:kcbZDykSQC Cited by: 2270

Accurate multiplex polony sequencing of an evolved bacterial genome J Shendure, GJ Porreca, NB Reppas, X Lin, JP McCutcheon, … Science 309 (5741), 1728-1732, 2005 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:qjMakFHDy7sC Cited by: 2232

Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems JE DiCarlo, JE Norville, P Mali, X Rios, J Aach, GM Church Nucleic acids research 41 (7), 4336-4343, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:J_g5lzvAfSwC Cited by: 2022

Programming cells by multiplex genome engineering and accelerated evolution HH Wang, FJ Isaacs, PA Carr, ZZ Sun, G Xu, CR Forest, GM Church Nature 460 (7257), 894-898, 2009 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:hqOjcs7Dif8C Cited by: 1832

A deep learning approach to antibiotic discovery JM Stokes, K Yang, K Swanson, W Jin, A Cubillos-Ruiz, NM Donghia, … Cell 180 (4), 688-702. e13, 2020 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:pZ2CosqRuhkC Cited by: 1791

Multiplex and homologous recombination–mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9 JF Li, JE Norville, J Aach, M McCormack, D Zhang, J Bush, GM Church, … Nature biotechnology 31 (8), 688-691, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:1sJd4Hv_s6UC Cited by: 1772

Cas9 as a versatile tool for engineering biology P Mali, KM Esvelt, GM Church Nature methods 10 (10), 957-963, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:ZHo1McVdvXMC Cited by: 1727

Analysis of optimality in natural and perturbed metabolic networks D Segre, D Vitkup, GM Church Proceedings of the national academy of sciences 99 (23), 15112-15117, 2002 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:zYLM7Y9cAGgC Cited by: 1648

Assessing computational tools for the discovery of transcription factor binding sites M Tompa, N Li, TL Bailey, GM Church, B De Moor, E Eskin, AV Favorov, … Nature biotechnology 23 (1), 137-144, 2005 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:9yKSN-GCB0IC Cited by: 1608

Highly efficient Cas9-mediated transcriptional programming A Chavez, J Scheiman, S Vora, BW Pruitt, M Tuttle, E PR Iyer, S Lin, … Nature methods 12 (4), 326-328, 2015 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:1tZ8xJnm2c8C Cited by: 1587

Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays R Drmanac, AB Sparks, MJ Callow, AL Halpern, NL Burns, BG Kermani, … Science 327 (5961), 78-81, 2010 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:ufrVoPGSRksC Cited by: 1555

Next-generation digital information storage in DNA GM Church, Y Gao, S Kosuri Science 337 (6102), 1628-1628, 2012 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:UxriW0iASnsC Cited by: 1449

Rapid prototyping of 3D DNA-origami shapes with caDNAno SM Douglas, AH Marblestone, S Teerapittayanon, A Vazquez, GM Church, … Nucleic acids research 37 (15), 5001-5006, 2009 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:O3NaXMp0MMsC Cited by: 1363

Computational identification of cis-regulatory elements associated with groups of functionally related genes in Saccharomyces cerevisiae JD Hughes, PW Estep, S Tavazoie, GM Church Journal of molecular biology 296 (5), 1205-1214, 2000 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:2osOgNQ5qMEC Cited by: 1351

Co-authors

Luhan Yang googlescholarauthor_id:RAPhZskAAAAJ

Kevin Esvelt googlescholarauthor_id:eJ9qDHMAAAAJ

Prashant Mali googlescholarauthor_id:blY0ilIAAAAJ

Marc Güell googlescholarauthor_id:VKWCESQAAAAJ

Jay Shendure googlescholarauthor_id:Gb8qVzQAAAAJ

Evan R. Daugharthy googlescholarauthorid:oxIYNUAAAAJ

Marc Joseph Lajoie googlescholarauthor_id:chKQSZUAAAAJ

Alejandro Chavez googlescholarauthor_id:sbYrDlMAAAAJ

Sriram Kosuri googlescholarauthor_id:ev8hXyEAAAAJ

James E. DiCarlo googlescholarauthor_id:rPc3yK4AAAAJ

Harris H. Wang googlescholarauthor_id:RFmkZ-EAAAAJ

James J Collins googlescholarauthor_id:te5DjPQAAAAJ

Morten O A Sommer googlescholarauthor_id:r2ZoOsMAAAAJ

Francois Vigneault googlescholarauthor_id:MBVGFIsAAAAJ

Adam H Marblestone googlescholarauthor_id:pRTuNPsAAAAJ

Daniel B. Goodman googlescholarauthorid:j1Z_l4AAAAJ

Reza Kalhor googlescholarauthor_id:aynAoP8AAAAJ

Ed Boyden googlescholarauthor_id:q2rHA5QAAAAJ

Kun Zhang googlescholarauthor_id:CYeurYgAAAAJ

Benjamin W Pruitt googlescholarauthor_id:kAoP9jUAAAAJ

Google Scholar

George Church Harvard Medical School http://arep.med.harvard.edu/ RNA-guided human genome engineering via Cas9 P Mali, L Yang, KM Esvelt, J Aach, M Guell, JE DiCarlo, JE Norville, … Science 339 (6121), 823-826, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:IjCSPb-OGe4C Cited by: 11531

Genomic sequencing. GM Church, W Gilbert Proceedings of the National Academy of Sciences 81 (7), 1991-1995, 1984 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:u5HHmVD_uO8C Cited by: 10442

Systematic determination of genetic network architecture S Tavazoie, JD Hughes, MJ Campbell, RJ Cho, GM Church Nature genetics 22 (3), 281-285, 1999 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:u-x6o8ySG0sC Cited by: 3266

Biclustering of expression data. Y Cheng, GM Church Ismb 8 (2000), 93-103, 2000 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:d1gkVwhDpl0C Cited by: 3139

The ENCODE (ENCyclopedia of DNA elements) project EA Feingold, PJ Good, MS Guyer, S Kamholz, L Liefer, K Wetterstrand, … Science 306 (5696), 636-640, 2004 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:KR6TXPE-FHQC Cited by: 2390

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering P Mali, J Aach, PB Stranges, KM Esvelt, M Moosburner, S Kosuri, L Yang, … Nature biotechnology 31 (9), 833-838, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:k_IJM867U9cC Cited by: 2281

A logic-gated nanorobot for targeted transport of molecular payloads SM Douglas, I Bachelet, GM Church Science 335 (6070), 831-834, 2012 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:kcbZDykSQC Cited by: 2270

Accurate multiplex polony sequencing of an evolved bacterial genome J Shendure, GJ Porreca, NB Reppas, X Lin, JP McCutcheon, … Science 309 (5741), 1728-1732, 2005 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:qjMakFHDy7sC Cited by: 2232

Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems JE DiCarlo, JE Norville, P Mali, X Rios, J Aach, GM Church Nucleic acids research 41 (7), 4336-4343, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:J_g5lzvAfSwC Cited by: 2022

Programming cells by multiplex genome engineering and accelerated evolution HH Wang, FJ Isaacs, PA Carr, ZZ Sun, G Xu, CR Forest, GM Church Nature 460 (7257), 894-898, 2009 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:hqOjcs7Dif8C Cited by: 1832

A deep learning approach to antibiotic discovery JM Stokes, K Yang, K Swanson, W Jin, A Cubillos-Ruiz, NM Donghia, … Cell 180 (4), 688-702. e13, 2020 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:pZ2CosqRuhkC Cited by: 1791

Multiplex and homologous recombination–mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9 JF Li, JE Norville, J Aach, M McCormack, D Zhang, J Bush, GM Church, … Nature biotechnology 31 (8), 688-691, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:1sJd4Hv_s6UC Cited by: 1772

Cas9 as a versatile tool for engineering biology P Mali, KM Esvelt, GM Church Nature methods 10 (10), 957-963, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:ZHo1McVdvXMC Cited by: 1727

Analysis of optimality in natural and perturbed metabolic networks D Segre, D Vitkup, GM Church Proceedings of the national academy of sciences 99 (23), 15112-15117, 2002 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:zYLM7Y9cAGgC Cited by: 1648

Assessing computational tools for the discovery of transcription factor binding sites M Tompa, N Li, TL Bailey, GM Church, B De Moor, E Eskin, AV Favorov, … Nature biotechnology 23 (1), 137-144, 2005 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:9yKSN-GCB0IC Cited by: 1608

Highly efficient Cas9-mediated transcriptional programming A Chavez, J Scheiman, S Vora, BW Pruitt, M Tuttle, E PR Iyer, S Lin, … Nature methods 12 (4), 326-328, 2015 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:1tZ8xJnm2c8C Cited by: 1587

Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays R Drmanac, AB Sparks, MJ Callow, AL Halpern, NL Burns, BG Kermani, … Science 327 (5961), 78-81, 2010 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:ufrVoPGSRksC Cited by: 1555

Next-generation digital information storage in DNA GM Church, Y Gao, S Kosuri Science 337 (6102), 1628-1628, 2012 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:UxriW0iASnsC Cited by: 1449

Rapid prototyping of 3D DNA-origami shapes with caDNAno SM Douglas, AH Marblestone, S Teerapittayanon, A Vazquez, GM Church, … Nucleic acids research 37 (15), 5001-5006, 2009 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:O3NaXMp0MMsC Cited by: 1363

Computational identification of cis-regulatory elements associated with groups of functionally related genes in Saccharomyces cerevisiae JD Hughes, PW Estep, S Tavazoie, GM Church Journal of molecular biology 296 (5), 1205-1214, 2000 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:2osOgNQ5qMEC Cited by: 1351

Co-authors

Luhan Yang googlescholarauthorid luhanyang.md:RAPhZskAAAAJ

Kevin Esvelt googlescholarauthorid kevinesvelt.md:eJ9qDHMAAAAJ

Prashant Mali googlescholarauthorid prashantmali.md:blY0ilIAAAAJ

Marc Güell googlescholarauthorid marcgüell.md:VKWCESQAAAAJ

Jay Shendure googlescholarauthorid jayshendure.md:Gb8qVzQAAAAJ

Evan R. Daugharthy googlescholarauthorid evanr.daugharthy.md:oxIYNUAAAAJ

Marc Joseph Lajoie googlescholarauthorid marcjoseph_lajoie.md:chKQSZUAAAAJ

Alejandro Chavez googlescholarauthorid alejandrochavez.md:sbYrDlMAAAAJ

Sriram Kosuri googlescholarauthorid sriramkosuri.md:ev8hXyEAAAAJ

James E. DiCarlo googlescholarauthorid jamese._dicarlo.md:rPc3yK4AAAAJ

Harris H. Wang googlescholarauthorid harrish._wang.md:RFmkZ-EAAAAJ

James J Collins googlescholarauthorid jamesj_collins.md:te5DjPQAAAAJ

Morten O A Sommer googlescholarauthorid mortenoasommer.md:r2ZoOsMAAAAJ

Francois Vigneault googlescholarauthorid francoisvigneault.md:MBVGFIsAAAAJ

Adam H Marblestone googlescholarauthorid adamh_marblestone.md:pRTuNPsAAAAJ

Daniel B. Goodman googlescholarauthorid danielb.goodman.md:j1Z_l4AAAAJ

Reza Kalhor googlescholarauthorid rezakalhor.md:aynAoP8AAAAJ

Ed Boyden googlescholarauthorid edboyden.md:q2rHA5QAAAAJ

Kun Zhang googlescholarauthorid kunzhang.md:CYeurYgAAAAJ

Benjamin W Pruitt googlescholarauthorid benjaminw_pruitt.md:kAoP9jUAAAAJ

Google Scholar

George Church

Harvard Medical School

http://arep.med.harvard.edu/

RNA-guided human genome engineering via Cas9 P Mali, L Yang, KM Esvelt, J Aach, M Guell, JE DiCarlo, JE Norville, … Science 339 (6121), 823-826, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:IjCSPb-OGe4C

Genomic sequencing. GM Church, W Gilbert Proceedings of the National Academy of Sciences 81 (7), 1991-1995, 1984 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:u5HHmVD_uO8C

Systematic determination of genetic network architecture S Tavazoie, JD Hughes, MJ Campbell, RJ Cho, GM Church Nature genetics 22 (3), 281-285, 1999 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:u-x6o8ySG0sC

Biclustering of expression data. Y Cheng, GM Church Ismb 8 (2000), 93-103, 2000 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:d1gkVwhDpl0C

The ENCODE (ENCyclopedia of DNA elements) project EA Feingold, PJ Good, MS Guyer, S Kamholz, L Liefer, K Wetterstrand, … Science 306 (5696), 636-640, 2004 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:KR6TXPE-FHQC

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering P Mali, J Aach, PB Stranges, KM Esvelt, M Moosburner, S Kosuri, L Yang, … Nature biotechnology 31 (9), 833-838, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:k_IJM867U9cC

A logic-gated nanorobot for targeted transport of molecular payloads SM Douglas, I Bachelet, GM Church Science 335 (6070), 831-834, 2012 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:kcbZDykSQC

Accurate multiplex polony sequencing of an evolved bacterial genome J Shendure, GJ Porreca, NB Reppas, X Lin, JP McCutcheon, … Science 309 (5741), 1728-1732, 2005 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:qjMakFHDy7sC

Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems JE DiCarlo, JE Norville, P Mali, X Rios, J Aach, GM Church Nucleic acids research 41 (7), 4336-4343, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:J_g5lzvAfSwC

Programming cells by multiplex genome engineering and accelerated evolution HH Wang, FJ Isaacs, PA Carr, ZZ Sun, G Xu, CR Forest, GM Church Nature 460 (7257), 894-898, 2009 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:hqOjcs7Dif8C

A deep learning approach to antibiotic discovery JM Stokes, K Yang, K Swanson, W Jin, A Cubillos-Ruiz, NM Donghia, … Cell 180 (4), 688-702. e13, 2020 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:pZ2CosqRuhkC

Multiplex and homologous recombination–mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9 JF Li, JE Norville, J Aach, M McCormack, D Zhang, J Bush, GM Church, … Nature biotechnology 31 (8), 688-691, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:1sJd4Hv_s6UC

Cas9 as a versatile tool for engineering biology P Mali, KM Esvelt, GM Church Nature methods 10 (10), 957-963, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:ZHo1McVdvXMC

Analysis of optimality in natural and perturbed metabolic networks D Segre, D Vitkup, GM Church Proceedings of the national academy of sciences 99 (23), 15112-15117, 2002 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:zYLM7Y9cAGgC

Assessing computational tools for the discovery of transcription factor binding sites M Tompa, N Li, TL Bailey, GM Church, B De Moor, E Eskin, AV Favorov, … Nature biotechnology 23 (1), 137-144, 2005 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:9yKSN-GCB0IC

Highly efficient Cas9-mediated transcriptional programming A Chavez, J Scheiman, S Vora, BW Pruitt, M Tuttle, E PR Iyer, S Lin, … Nature methods 12 (4), 326-328, 2015 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:1tZ8xJnm2c8C

Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays R Drmanac, AB Sparks, MJ Callow, AL Halpern, NL Burns, BG Kermani, … Science 327 (5961), 78-81, 2010 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:ufrVoPGSRksC

Next-generation digital information storage in DNA GM Church, Y Gao, S Kosuri Science 337 (6102), 1628-1628, 2012 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:UxriW0iASnsC

Rapid prototyping of 3D DNA-origami shapes with caDNAno SM Douglas, AH Marblestone, S Teerapittayanon, A Vazquez, GM Church, … Nucleic acids research 37 (15), 5001-5006, 2009 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:O3NaXMp0MMsC

Computational identification of cis-regulatory elements associated with groups of functionally related genes in Saccharomyces cerevisiae JD Hughes, PW Estep, S Tavazoie, GM Church Journal of molecular biology 296 (5), 1205-1214, 2000 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=SfDzdgEAAAAJ&citationforview=SfDzdgEAAAAJ:2osOgNQ5qMEC

Co-authors

Luhan Yang googlescholarauthorid luhanyang.md:RAPhZskAAAAJ

Kevin Esvelt googlescholarauthorid kevinesvelt.md:eJ9qDHMAAAAJ

Prashant Mali googlescholarauthorid prashantmali.md:blY0ilIAAAAJ

Marc Güell googlescholarauthorid marcgüell.md:VKWCESQAAAAJ

Jay Shendure googlescholarauthorid jayshendure.md:Gb8qVzQAAAAJ

Evan R. Daugharthy googlescholarauthorid evanr.daugharthy.md:oxIYNUAAAAJ

Marc Joseph Lajoie googlescholarauthorid marcjoseph_lajoie.md:chKQSZUAAAAJ

Alejandro Chavez googlescholarauthorid alejandrochavez.md:sbYrDlMAAAAJ

Sriram Kosuri googlescholarauthorid sriramkosuri.md:ev8hXyEAAAAJ

James E. DiCarlo googlescholarauthorid jamese._dicarlo.md:rPc3yK4AAAAJ

Harris H. Wang googlescholarauthorid harrish._wang.md:RFmkZ-EAAAAJ

James J Collins googlescholarauthorid jamesj_collins.md:te5DjPQAAAAJ

Morten O A Sommer googlescholarauthorid mortenoasommer.md:r2ZoOsMAAAAJ

Francois Vigneault googlescholarauthorid francoisvigneault.md:MBVGFIsAAAAJ

Adam H Marblestone googlescholarauthorid adamh_marblestone.md:pRTuNPsAAAAJ

Daniel B. Goodman googlescholarauthorid danielb.goodman.md:j1Z_l4AAAAJ

Reza Kalhor googlescholarauthorid rezakalhor.md:aynAoP8AAAAJ

Ed Boyden googlescholarauthorid edboyden.md:q2rHA5QAAAAJ

Kun Zhang googlescholarauthorid kunzhang.md:CYeurYgAAAAJ

Benjamin W Pruitt googlescholarauthorid benjaminw_pruitt.md:kAoP9jUAAAAJ

Youtube Videos

Youtube Title: George Church | The Future of Genome Editing

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Youtube Channel Name: Harvard Medical School

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George Church | The Future of Genome Editing

Youtube Title: George Church at TEDMED 2010

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George Church at TEDMED 2010

Youtube Title: George Church | Multiplex Failures

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George Church | Multiplex Failures

Youtube Title: Scientist George Church talks about accepting donations from Jeffrey Epstein

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Scientist George Church talks about accepting donations from Jeffrey Epstein

Youtube Title: Engineering Human Genomes & Environments with Dr. George M. Church

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Engineering Human Genomes & Environments with Dr. George M. Church

Youtube Title: Engineering Human Genomes & Environments - Dr. George M. Church

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Engineering Human Genomes & Environments - Dr. George M. Church

Youtube Title: George Church on Designer Babies, Age Reversal and Woolly Mammoth DNA | Amanpour and Company

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George Church on Designer Babies, Age Reversal and Woolly Mammoth DNA | Amanpour and Company

Youtube Title: George Church on the Biggest Thing to Happen to Biomedicine in Decades

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George Church on the Biggest Thing to Happen to Biomedicine in Decades

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Youtube Title: DNA: George Church at TEDxCERN

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DNA: George Church at TEDxCERN

Youtube Title: Convergent Innovation in Genomic Medicines by George Church, Ph.D.

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Youtube Channel Name: Danaher Corporation

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Convergent Innovation in Genomic Medicines by George Church, Ph.D.

Youtube Title: George Church: Exploring Genomics | WIRED Health

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Youtube Channel Name: WIRED Events

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George Church: Exploring Genomics | WIRED Health

Youtube Title: George Church: Breaking Boundaries of Possibility in Gene Therapy, Moderated by Simon Sakhai

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Youtube Channel Name: Oxford Society of Ageing and Longevity

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George Church: Breaking Boundaries of Possibility in Gene Therapy, Moderated by Simon Sakhai

Youtube Title: Defeating Nature's Deadliest Killers with Harvard Scientist George Church

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Youtube Channel Name: Upworthy Science

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Defeating Nature's Deadliest Killers with Harvard Scientist George Church

Youtube Title: Reversing Human Aging | George Church | TEDxBeaconStreetSalon

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Reversing Human Aging | George Church | TEDxBeaconStreetSalon

Youtube Title: The Future of Synthetic Biology with Prof. George Church (Harvard Medical School) || HAE

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Youtube Channel Name: Harvard Alumni Entrepreneurs

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The Future of Synthetic Biology with Prof. George Church (Harvard Medical School) || HAE

Youtube Title: 7/18/2018 - DSC - George Church: Reading & Editing Genomes

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Youtube Channel Name: Argonne National Laboratory

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7/18/2018 - DSC - George Church: Reading & Editing Genomes

Youtube Title: Unite To Cure: John Leonard, MD, George M. Church, PhD, and Samarth Kulkarni, PhD

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Youtube Channel Name: The Cura Foundation

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Unite To Cure: John Leonard, MD, George M. Church, PhD, and Samarth Kulkarni, PhD

Youtube Title: George Church & the Mammoth HD 720p

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Youtube Channel Name: PZ Myers

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George Church & the Mammoth HD 720p