doi.bio/james_s_fraser

James S Fraser

Early Life and Education

James Outram Fraser was born in London in 1886, the third son of James Fraser and Annie Palmer. Fraser's parents divorced when he was a teenager, and he moved to Letchworth with his mother, who was a devout Christian and a significant influence on his spiritual development. Fraser attended Imperial College London, where he studied engineering and graduated with a degree in the subject. He was also a talented pianist and held a recital in his twenties.

Missionary Work in China

Fraser dedicated his life to missionary work in 1908, joining the China Inland Mission (CIM). He arrived in China at 22, travelling to Shanghai, Hong Kong, and eventually the mountainous region of China's southwest. He learned the Lisu language and began his work among the Lisu people, a Tibeto-Burmese minority living in the high mountains along the borders of China and Burma. Fraser was able to communicate with the Lisu through Chinese and adapted well to their way of life, living in their mud-floor huts.

Fraser spent nearly thirty years working among the Lisu and is best known for developing the Fraser script, an alphabet for the Lisu language. He used this script to translate the New Testament, as well as a catechism and hymns, into the Lisu language. Fraser also designed a written musical notation for transcribing the Lisu's oral history songs.

Fraser was known for his ability to organise the Lisu people into strong, self-supporting indigenous churches. He emphasised the importance of self-sufficiency and discouraged dependency on foreign funds, believing that "foreign money and foreign control would build a foreign church, and a weak one". Fraser trained the Lisu converts to be self-governing and self-propagating, with their own elders, deacons, pastors, and evangelists.

Personal Life and Death

Fraser married Roxie Dymond, the daughter of a Methodist missionary, in 1929. They had three daughters together. Fraser died in September 1938 in Baoshan, Yunnan, at the age of 52, from malignant cerebral malaria.

Legacy

Fraser is remembered as one of the most successful Christian missionaries to East Asia in modern times. The Lisu Christian church he helped establish continued to grow and thrive, even amid Communist persecution and forced abortions. In recent years, the Lisu church has gained recognition from the Chinese government for its positive contributions to society, and they have been granted full freedom to worship and propagate their faith.

Bibliography

Behind the Ranges: The Life-Changing Story of J.O. Fraser, by Mrs. Howard Taylor (Mary Geraldine Guinness)
Mountain Rain: A Biography of James O. Fraser, by Eileen Fraser Crossman
A Memoir of J. O. Fraser, by Mrs. J. O. Fraser
Numerous letters and diaries, which have been referenced in the biographies above

Google Scholar Profile

James S Fraser)

Google Scholar

James S. Fraser Professor, University of California San Francisco http://fraserlab.com/ A SARS-CoV-2 protein interaction map reveals targets for drug repurposing DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier, KM White, … Nature 583 (7816), 459-468, 2020 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=j3iaoR8AAAAJ&citationforview=j3iaoR8AAAAJ:a2necdfpwlEC Cited by: 4466

EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy BA Barad, N Echols, RYR Wang, Y Cheng, F DiMaio, PD Adams, … Nature methods 12 (10), 943-946, 2015 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=j3iaoR8AAAAJ&citationforview=j3iaoR8AAAAJ:gV6rEsy15s0C Cited by: 753

Promoting transparency and reproducibility in enhanced molecular simulations M Bonomi, G Bussi, C Camilloni, GA Tribello, P Banáš, A Barducci, … Nature methods 16 (8), 670-673, 2019 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=j3iaoR8AAAAJ&citationforview=j3iaoR8AAAAJ:oYLFIHfuHKwC Cited by: 684

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms DE Gordon, J Hiatt, M Bouhaddou, VV Rezelj, S Ulferts, H Braberg, … Science 370 (6521), eabe9403, 2020 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=j3iaoR8AAAAJ&citationforview=j3iaoR8AAAAJ:M0j1y4EgrScC Cited by: 633

Accessing protein conformational ensembles using room-temperature X-ray crystallography JS Fraser, H van den Bedem, AJ Samelson, PT Lang, JM Holton, … Proceedings of the National Academy of Sciences 108 (39), 16247-16252, 2011 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=j3iaoR8AAAAJ&citationforview=j3iaoR8AAAAJ:_FxGoFyzp5QC Cited by: 603

Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine BB Williams, AH Van Benschoten, P Cimermancic, MS Donia, … Cell host & microbe 16 (4), 495-503, 2014 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=j3iaoR8AAAAJ&citationforview=j3iaoR8AAAAJ:e84hm74t-eoC Cited by: 574

Hidden alternative structures of proline isomerase essential for catalysis JS Fraser, MW Clarkson, SC Degnan, R Erion, D Kern, T Alber Nature 462 (7273), 669-673, 2009 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=j3iaoR8AAAAJ&citationforview=j3iaoR8AAAAJ:Tyk-4Ss8FVUC Cited by: 544

Large language models generate functional protein sequences across diverse families A Madani, B Krause, ER Greene, S Subramanian, BP Mohr, JM Holton, … Nature Biotechnology 41 (8), 1099-1106, 2023 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=j3iaoR8AAAAJ&citationforview=j3iaoR8AAAAJ:eAUscmXIlQ8C Cited by: 477

Systematic functional prioritization of protein posttranslational modifications P Beltrao, V Albanèse, LR Kenner, DL Swaney, A Burlingame, J Villén, … Cell 150 (2), 413-425, 2012 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=j3iaoR8AAAAJ&citationforview=j3iaoR8AAAAJ:hqOjcs7Dif8C Cited by: 443

Automated structure refinement of macromolecular assemblies from cryo-EM maps using Rosetta RYR Wang, Y Song, BA Barad, Y Cheng, JS Fraser, F DiMaio Elife 5, e17219, 2016 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=j3iaoR8AAAAJ&citationforview=j3iaoR8AAAAJ:q1zXlPLtbUIC Cited by: 401

Effects of α-tubulin acetylation on microtubule structure and stability L Eshun-Wilson, R Zhang, D Portran, MV Nachury, DB Toso, T Löhr, … Proceedings of the National Academy of Sciences 116 (21), 10366-10371, 2019 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=j3iaoR8AAAAJ&citationforview=j3iaoR8AAAAJ:K4-iKlO5MD4C Cited by: 292

Integrative, dynamic structural biology at atomic resolution - it's about time H van den Bedem, JS Fraser Nature methods 12 (4), 307-318, 2015 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=j3iaoR8AAAAJ&citationforview=j3iaoR8AAAAJ:oqD4_j7ulsYC Cited by: 240

Ig-like domains on bacteriophages: a tale of promiscuity and deceit JS Fraser, Z Yu, KL Maxwell, AR Davidson Journal of molecular biology 359 (2), 496-507, 2006 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=j3iaoR8AAAAJ&citationforview=j3iaoR8AAAAJ:u5HHmVD_uO8C Cited by: 226

CryptoSite: expanding the druggable proteome by characterization and prediction of cryptic binding sites P Cimermancic, P Weinkam, TJ Rettenmaier, L Bichmann, DA Keedy, … Journal of molecular biology 428 (4), 709-719, 2016 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=j3iaoR8AAAAJ&citationforview=j3iaoR8AAAAJ:X5YyAB84Iw4C Cited by: 196

Preprints for the life sciences JM Berg, N Bhalla, PE Bourne, M Chalfie, DG Drubin, JS Fraser, … Science 352 (6288), 899-901, 2016 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=j3iaoR8AAAAJ&citationforview=j3iaoR8AAAAJ:8uzoZH4hB9AC Cited by: 192

Integrated description of protein dynamics from room-temperature X-ray crystallography and NMR RB Fenwick, H van den Bedem, JS Fraser, PE Wright Proceedings of the National Academy of Sciences 111 (4), E445-E454, 2014 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=j3iaoR8AAAAJ&citationforview=j3iaoR8AAAAJ:as0KMg8qHbkC Cited by: 180

Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography DA Keedy, LR Kenner, M Warkentin, RA Woldeyes, JB Hopkins, … Elife 4, e07574, 2015 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=j3iaoR8AAAAJ&citationforview=j3iaoR8AAAAJ:AFmTUeZ1pmEC Cited by: 174

Automated electron‐density sampling reveals widespread conformational polymorphism in proteins PT Lang, HL Ng, JS Fraser, JE Corn, N Echols, M Sales, JM Holton, … Protein Science 19 (7), 1420-1431, 2010 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=j3iaoR8AAAAJ&citationforview=j3iaoR8AAAAJ:W7OEmFMy1HYC Cited by: 172

From structure to systems: high-resolution, quantitative genetic analysis of RNA polymerase II H Braberg, H Jin, EA Moehle, YA Chan, S Wang, M Shales, JJ Benschop, … Cell 154 (4), 775-788, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=j3iaoR8AAAAJ&citationforview=j3iaoR8AAAAJ:4TOpqqG69KYC Cited by: 162

Automated identification of functional dynamic contact networks from X-ray crystallography H Van Den Bedem, G Bhabha, K Yang, PE Wright, JS Fraser Nature methods 10 (9), 896-902, 2013 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=j3iaoR8AAAAJ&citationforview=j3iaoR8AAAAJ:ULOm3_A8WrAC Cited by: 148

Co-authors

Henry van den Bedem sWo3_34AAAAJ

James Holton X8ECs3UAAAAJ

Daniel A. Keedy TVaqcVwAAAAJ

Michael Thompson KDvVpWYAAAAJ

Benjamin A. Barad XDH9FrwAAAAJ

Paul D. Adams K08_cxoAAAAJ

Andrew H. Van Benschoten 6YlS0rQAAAAJ

Lillian Kenner UrlSRv0AAAAJ

Rahel A. Woldeyes kFoaho8AAAAJ

Michael E. Wall s3zbV24AAAAJ

Frank DiMaio jQpFYpIAAAAJ

Nevan Krogan _JFStaIAAAAJ

Lin Liu 5kUDcJ0AAAAJ

Aaron S Brewster f-rQ8e4AAAAJ

Ray Yu-Ruei Wang qFEfJ00AAAAJ

Aina E Cohen eJcN6_sAAAAJ

Frank von Delft uZpTG1kAAAAJ

Ali Madani ZEDT0-cAAAAJ

Alexander M. Wolff EqoaChsAAAAJ

Tanja Kortemme -JEkXJkAAAAJ

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Co-authors

Henry van den Bedem googlescholarauthorid:sWo334AAAAJ

James Holton googlescholarauthor_id:X8ECs3UAAAAJ

Daniel A. Keedy googlescholarauthor_id:TVaqcVwAAAAJ

Michael Thompson googlescholarauthor_id:KDvVpWYAAAAJ

Benjamin A. Barad googlescholarauthor_id:XDH9FrwAAAAJ

Paul D. Adams googlescholarauthorid:K08cxoAAAAJ

Andrew H. Van Benschoten googlescholarauthor_id:6YlS0rQAAAAJ

Lillian Kenner googlescholarauthor_id:UrlSRv0AAAAJ

Rahel A. Woldeyes googlescholarauthor_id:kFoaho8AAAAJ

Michael E. Wall googlescholarauthor_id:s3zbV24AAAAJ

Frank DiMaio googlescholarauthor_id:jQpFYpIAAAAJ

Nevan Krogan googlescholarauthorid:JFStaIAAAAJ

Lin Liu googlescholarauthor_id:5kUDcJ0AAAAJ

Aaron S Brewster googlescholarauthor_id:f-rQ8e4AAAAJ

Ray Yu-Ruei Wang googlescholarauthor_id:qFEfJ00AAAAJ

Aina E Cohen googlescholarauthorid:eJcN6sAAAAJ

Frank von Delft googlescholarauthor_id:uZpTG1kAAAAJ

Ali Madani googlescholarauthor_id:ZEDT0-cAAAAJ

Alexander M. Wolff googlescholarauthor_id:EqoaChsAAAAJ

Tanja Kortemme googlescholarauthor_id:-JEkXJkAAAAJ

Google Scholar

Co-authors

Henry van den Bedem googlescholarauthorid henryvandenbedem.md:sWo3_34AAAAJ

James Holton googlescholarauthorid jamesholton.md:X8ECs3UAAAAJ

Daniel A. Keedy googlescholarauthorid daniela._keedy.md:TVaqcVwAAAAJ

Michael Thompson googlescholarauthorid michaelthompson.md:KDvVpWYAAAAJ

Benjamin A. Barad googlescholarauthorid benjamina._barad.md:XDH9FrwAAAAJ

Paul D. Adams googlescholarauthorid pauld.adams.md:K08cxoAAAAJ

Andrew H. Van Benschoten googlescholarauthorid andrewh.vanbenschoten.md:6YlS0rQAAAAJ

Lillian Kenner googlescholarauthorid lilliankenner.md:UrlSRv0AAAAJ

Rahel A. Woldeyes googlescholarauthorid rahela._woldeyes.md:kFoaho8AAAAJ

Michael E. Wall googlescholarauthorid michaele._wall.md:s3zbV24AAAAJ

Frank DiMaio googlescholarauthorid frankdimaio.md:jQpFYpIAAAAJ

Nevan Krogan googlescholarauthorid nevankrogan.md:_JFStaIAAAAJ

Lin Liu googlescholarauthorid linliu.md:5kUDcJ0AAAAJ

Aaron S Brewster googlescholarauthorid aarons_brewster.md:f-rQ8e4AAAAJ

Ray Yu-Ruei Wang googlescholarauthorid rayyu-ruei_wang.md:qFEfJ00AAAAJ

Aina E Cohen googlescholarauthorid ainaecohen.md:eJcN6sAAAAJ

Frank von Delft googlescholarauthorid frankvon_delft.md:uZpTG1kAAAAJ

Ali Madani googlescholarauthorid alimadani.md:ZEDT0-cAAAAJ

Alexander M. Wolff googlescholarauthorid alexanderm._wolff.md:EqoaChsAAAAJ

Tanja Kortemme googlescholarauthorid tanjakortemme.md:-JEkXJkAAAAJ

Google Scholar

James S. Fraser

Professor, University of California San Francisco

http://fraserlab.com/

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier, KM White, … Nature 583 (7816), 459-468, 2020 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=j3iaoR8AAAAJ&citationforview=j3iaoR8AAAAJ:a2necdfpwlEC