doi.bio/jonathan_frazer
Jonathan Frazer
Biography
Jonathan Frazer is a researcher in the fields of machine learning, computational biology, statistics, and theoretical physics. He currently leads a research group at the Centre for Genomic Regulation in Barcelona alongside Mafalda Dias.
Education
Frazer received his PhD in Theoretical Physics from the University of Sussex in 2013.
Career History
- 2022-present: Group Leader, Centre for Genomic Regulation (CRG)
- 2018-2022: Senior Postdoctoral Fellow, Harvard Medical School
- 2015-2018: Fellow, The Deutsches Elektronen-Synchrotron (DESY)
- 2013-2015: Postdoctoral Researcher, University of the Basque Country/University College London
Research Focus
Frazer's research focuses on developing generative models of the effect of genetic variation, with an emphasis on identifying variations in humans that impact disease risk. He aims to develop methods that will enable the effective utilisation of whole-genome sequencing for diagnosis and preventative care.
Notable Works
- ProteinGym: ProteinGym is a set of Deep Mutational Scanning (DMS) assays used to assess the ability of mutation effect predictors to predict the fitness of mutated proteins.
- EVE predictions: Predictions for the clinical significance of 36 million variants across 3,219 disease genes, using variational autoencoders trained on diverse protein sequences.
- The Transport Method: A technique for computing two-point and three-point correlation functions of fluctuations generated in an inflationary epoch during the early universe.
- MULTIMODECODE: A Fortran 95/2000 package for the numerical exploration of multifield inflation models.
Jonathan Frazer
Overview
Jonathan Frazer is a researcher in the fields of computational biology, statistics, machine learning, and theoretical physics. He currently leads a research group at the Centre for Genomic Regulation in Barcelona, Spain, alongside Mafalda Dias.
Education
Frazer received his PhD in Theoretical Physics from the University of Sussex in 2013.
Career History
- 2022-present: Group Leader, Centre for Genomic Regulation (CRG), Barcelona, Spain
- 2018-2022: Senior Postdoctoral Fellow, Harvard Medical School
- 2015-2018: Fellow, The Deutsches Elektronen-Synchrotron (DESY)
- 2013-2015: Postdoctoral Researcher, University of the Basque Country and University College London
- 2013: PhD, Theoretical Physics, University of Sussex
Research Focus
Frazer's research focuses on developing generative models to understand the effects of genetic variation and identify variations that impact disease risk in humans. He aims to maximise the benefit of sequencing all life on Earth for human health and to utilise whole-genome sequencing for diagnosis and preventative care.
Notable Works
- ProteinGym: An extensive set of Deep Mutational Scanning (DMS) assays to assess the ability of mutation effect predictors to predict the fitness of mutated proteins.
- EVE predictions: Predictions for the clinical significance of 36 million variants across 3,219 disease genes using variational autoencoders trained on protein sequences from diverse organisms.
- The Transport Method: A technique for computing two-point and three-point correlation functions of fluctuations generated during the early universe's inflationary epoch.
- MULTIMODECODE: A Fortran 95/2000 package for the numerical exploration of multifield inflation models.
Youtube Videos
Youtube Title: MIA: Mafalda Dias & Jonathan Frazer, interpreting gene variants; Jung-Eun (June) Shin, Ab libraries
Youtube Link: link
Youtube Channel Name: Broad Institute
Youtube Channel Link: https://www.youtube.com/@broadinstitute
MIA: Mafalda Dias & Jonathan Frazer, interpreting gene variants; Jung-Eun (June) Shin, Ab libraries
Youtube Title: Jonathan Franzen talks with David Remnick - The New Yorker Festival - The New Yorker
Youtube Link: link
Youtube Channel Name: The New Yorker
Youtube Channel Link: https://www.youtube.com/@newyorker
Jonathan Franzen talks with David Remnick - The New Yorker Festival - The New Yorker
Youtube Title: CASP AI-ZOOM Sep 13, Mafalda Dias and Jonathan Frazer
Youtube Link: link
Youtube Channel Name: Introduction to Bioinformatics by Arne Elofsson at Stockholm University
Youtube Channel Link: https://www.youtube.com/@introductiontobioinformati9910
CASP AI-ZOOM Sep 13, Mafalda Dias and Jonathan Frazer
Youtube Title: Kipoi Seminar - Mafalda Dias & Jonathan Frazer (Harvard Medical School)
Youtube Link: link
Youtube Channel Name: Kipoi Seminar
Youtube Channel Link: https://www.youtube.com/@kipoiseminar1846
Kipoi Seminar - Mafalda Dias & Jonathan Frazer (Harvard Medical School)
Youtube Title: Jonathan Frazer Lessard - "New Hampshire"
Youtube Link: link
Youtube Channel Name: JoePublicFilms
Youtube Channel Link: https://www.youtube.com/@JoePublicFilms
Jonathan Frazer Lessard - "New Hampshire"
Youtube Title: Fraser & Jonathan - Last Song
Youtube Link: link
Youtube Channel Name: Ovik6280
Youtube Channel Link: https://www.youtube.com/@ovanes
Fraser & Jonathan - Last Song
Youtube Title: #11 Missing Jonathan Fraser Honolulu Hawaii
Youtube Link: link
Youtube Channel Name: MISSING / UNSOLVED CRIME
Youtube Channel Link: https://www.youtube.com/@missingandunsolvedcrime
#11 Missing Jonathan Fraser Honolulu Hawaii
Youtube Title: Send The Latter Rain - Reveal , Renew, Restore - Bro Jonathan Frazer (FL Youth Weekend 2023)
Youtube Link: link
Youtube Channel Name: MZSA COG 7th Day
Youtube Channel Link: https://www.youtube.com/@MZSACOG7thDay
Send The Latter Rain - Reveal , Renew, Restore - Bro Jonathan Frazer (FL Youth Weekend 2023)
Youtube Title: Jonathan Frazer Wrote The Laziest Non Fiction I've Ever Read
Youtube Link: link
Youtube Channel Name: Antzero Books
Youtube Channel Link: https://www.youtube.com/@antzerobooks
Jonathan Frazer Wrote The Laziest Non Fiction I've Ever Read
Youtube Title: Discover Communion
Youtube Link: link
Youtube Channel Name: Jonathan Frazer
Youtube Channel Link: https://www.youtube.com/@bobhyphen
Discover Communion
Youtube Title: The State of Man - Bro Jonathan Frazer (CONVENTION 2022)
Youtube Link: link
Youtube Channel Name: MZSA COG 7th Day
Youtube Channel Link: https://www.youtube.com/@MZSACOG7thDay
The State of Man - Bro Jonathan Frazer (CONVENTION 2022)
Youtube Title: JK Rowling Stepped In To Defend Henry Fraser Online | The Jonathan Ross Show
Youtube Link: link
Youtube Channel Name: The Jonathan Ross Show
Youtube Channel Link: https://www.youtube.com/@OfficialJonathanRoss
JK Rowling Stepped In To Defend Henry Fraser Online | The Jonathan Ross Show
Youtube Title: 15th of Vlune
Youtube Link: link
Youtube Channel Name: Jonathan Frazer
Youtube Channel Link: https://www.youtube.com/@bobhyphen
15th of Vlune
Youtube Title: 19th of Marvlog/34th of Vlent
Youtube Link: link
Youtube Channel Name: Jonathan Frazer
Youtube Channel Link: https://www.youtube.com/@bobhyphen
19th of Marvlog/34th of Vlent
Youtube Title: 9th of Marvlog/24th of Vlent
Youtube Link: link
Youtube Channel Name: Jonathan Frazer
Youtube Channel Link: https://www.youtube.com/@bobhyphen
9th of Marvlog/24th of Vlent