doi.bio/stephen_k_burley

Stephen K. Burley

Stephen Kevin Burley is a British-born scientist, naturalised in Canada and the United States, specialising in oncology and structural biology. Burley is currently a University Professor and Henry Rutgers Chair at Rutgers, The State University of New Jersey, where he directs the RCSB Protein Data Bank, the Center for Integrative Proteomics Research, and the Institute for Quantitative Biomedicine. He is also a member of the Rutgers Cancer Institute of New Jersey, where he co-leads the Cancer Pharmacology Research Program.

Education

Burley received a Bachelor of Science in physics from the University of Western Ontario in 1980 and a DPhil in molecular biophysics from Oxford University in 1983 as a Rhodes Scholar. He then went on to obtain an MD from Harvard Medical School in 1987.

Career

Burley has had a long and distinguished career in academia and industry. He was a faculty member at the Howard Hughes Medical Institute and Rockefeller University. In 2001, he co-founded Prospect Genomics, Inc., a computational genomics pharma company that was acquired by SGX Pharmaceuticals in 2001. Following the acquisition, Burley became the Chief Scientific Officer and Senior Vice President of SGX Pharmaceuticals. In 2008, SGX Pharmaceuticals was merged with Eli Lilly, where Burley became a Distinguished Lilly Research Scholar. In 2012, Burley joined Rutgers University as Director of the Center for Integrative Proteomics Research and succeeded Prof. Helen Berman as director of the RCSB PDB in 2014.

Research

Burley's research interests include structural biology, proteomics, bioinformatics, structure/fragment-based drug discovery, and clinical medicine/oncology. He has authored or co-authored over 340 scholarly scientific articles and is a member of the Editorial Board for Oncogene.

Awards and Honours

Fellow of the Royal Society of Canada (elected 1995)
Fellow of the New York Academy of Sciences
Fellow of the American Crystallographic Association
Doctor of Science (Honoris causa) from the University of Western Ontario

Google Scholar Profile

Stephen K Burley)

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Stephen K. Burley, M.D., D.Phil. Institute for Quantitative Biomedicine, Rutgers University N/A Weight-reducing effects of the plasma protein encoded by the< em> obese gene. JL Halaas, KS Gajiwala, M Maffei, SL Cohen Science, 1995 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=7MuXtUgAAAAJ&citationforview=7MuXtUgAAAAJ:L7CI7m0gUJcC Cited by: 6357

Aromatic-aromatic interaction: a mechanism of protein structure stabilization. SK Burley, GA Petsko Science (New York, NY) 229 (4708), 23, 1985 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=7MuXtUgAAAAJ&citationforview=7MuXtUgAAAAJ:iH-uZ7U-co4C Cited by: 3100

Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5 KL Clark, ED Halay, E Lai, SK Burley Nature 364 (6436), 412-420, 1993 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=7MuXtUgAAAAJ&citationforview=7MuXtUgAAAAJ:mB3voiENLucC Cited by: 1627

Co-crystal structure of TBP recognizing the minor groove of a TATA element JL Kim, DB Nikolov, SK Burley Nature 365 (6446), 520-527, 1993 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=7MuXtUgAAAAJ&citationforview=7MuXtUgAAAAJ:HDshCWvjkbEC Cited by: 1471

RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology … SK Burley, C Bhikadiya, C Bi, S Bittrich, L Chen, GV Crichlow, CH Christie, … Nucleic acids research 49 (D1), D437-D451, 2021 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=7MuXtUgAAAAJ&citationforview=7MuXtUgAAAAJ:lYAcb2jw7qUC Cited by: 1173

Hierarchical phosphorylation of the translation inhibitor 4E-BP1 AC Gingras, B Raught, SP Gygi, A Niedzwiecka, M Miron, SK Burley, … Genes & development 15 (21), 2852-2864, 2001 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=7MuXtUgAAAAJ&citationforview=7MuXtUgAAAAJ:RHpTSmoSYBkC Cited by: 1143

RCSB Protein Data Bank: biological macromolecular structures enabling research and education in fundamental biology, biomedicine, biotechnology and energy SK Burley, HM Berman, C Bhikadiya, C Bi, L Chen, L Di Costanzo, … Nucleic acids research 47 (D1), D464-D474, 2019 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=7MuXtUgAAAAJ&citationforview=7MuXtUgAAAAJ:rbm3iO8VlycC Cited by: 1063

The RCSB protein data bank: integrative view of protein, gene and 3D structural information PW Rose, A Prlić, A Altunkaya, C Bi, AR Bradley, CH Christie, … Nucleic acids research, gkw1000, 2016 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=7MuXtUgAAAAJ&citationforview=7MuXtUgAAAAJ:j7_hQOaDUrUC Cited by: 1050

Biochemistry and structural biology of transcription factor IID (TFIID) SK Burley, RG Roeder Annual review of biochemistry 65 (1), 769-799, 1996 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=7MuXtUgAAAAJ&citationforview=7MuXtUgAAAAJ:bEWYMUwI8FkC Cited by: 1027

Weakly polar interactions in proteins SK Burley, GA Petsko Advances in protein chemistry 39, 125-189, 1988 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=7MuXtUgAAAAJ&citationforview=7MuXtUgAAAAJ:TFP_iSt0sucC Cited by: 1018

Protein production and purification Architecture et Fonction des Macromolécules Biologiques Vincentelli Renaud 4 … Nature methods 5 (2), 135-146, 2008 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=7MuXtUgAAAAJ&citationforview=7MuXtUgAAAAJ:HeT0ZceujKMC Cited by: 992

Amino-aromatic interactions in proteins SK Burley, GA Petsko Febs Letters 203 (2), 139-143, 1986 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=7MuXtUgAAAAJ&citationforview=7MuXtUgAAAAJ:isC4tDSrTZIC Cited by: 934

Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain AR Ferré-D'Amaré, GC Prendergast, EB Ziff, SK Burley Nature 363 (6424), 38-45, 1993 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=7MuXtUgAAAAJ&citationforview=7MuXtUgAAAAJ:TQgYirikUcIC Cited by: 933

Cocrystal structure of the messenger RNA 5′ cap-binding protein (eIF4E) bound to 7-methyl-GDP J Marcotrigiano, AC Gingras, N Sonenberg, SK Burley Cell 89 (6), 951-961, 1997 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=7MuXtUgAAAAJ&citationforview=7MuXtUgAAAAJ:_Qo2XoVZTnwC Cited by: 845

Protein Data Bank (PDB): the single global macromolecular structure archive SK Burley, HM Berman, GJ Kleywegt, JL Markley, H Nakamura, … Protein crystallography: methods and protocols, 627-641, 2017 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=7MuXtUgAAAAJ&citationforview=7MuXtUgAAAAJ:-mN3Mh-tlDkC Cited by: 803

Crystal structure of a TFIIB–TBP–TATA-element ternary complex DB Nikolov, H Chen, ED Halay, AA Usheva, K Hisatake, DK Lee, … Nature 377 (6545), 119-128, 1995 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=7MuXtUgAAAAJ&citationforview=7MuXtUgAAAAJ:R3hNpaxXUhUC Cited by: 763

Mol* Viewer: modern web app for 3D visualization and analysis of large biomolecular structures D Sehnal, S Bittrich, M Deshpande, R Svobodová, K Berka, V Bazgier, … Nucleic acids research 49 (W1), W431-W437, 2021 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=7MuXtUgAAAAJ&citationforview=7MuXtUgAAAAJ:eI34FqJmdUoC Cited by: 741

Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin PG Leiman, M Basler, UA Ramagopal, JB Bonanno, JM Sauder, … Proceedings of the National Academy of Sciences 106 (11), 4154-4159, 2009 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=7MuXtUgAAAAJ&citationforview=7MuXtUgAAAAJ:4OULZ7Gr8RgC Cited by: 720

Winged helix proteins KS Gajiwala, SK Burley Current opinion in structural biology 10 (1), 110-116, 2000 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=7MuXtUgAAAAJ&citationforview=7MuXtUgAAAAJ:4JMBOYKVnBMC Cited by: 719

A standard reference frame for the description of nucleic acid base-pair geometry WK Olson, M Bansal, SK Burley, RE Dickerson, M Gerstein, SC Harvey, … Journal of molecular biology 313 (1), 229-237, 2001 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=7MuXtUgAAAAJ&citationforview=7MuXtUgAAAAJ:M3NEmzRMIkIC Cited by: 696

Google Scholar

Stephen K. Burley, M.D., D.Phil.

Institute for Quantitative Biomedicine, Rutgers University

N/A

Weight-reducing effects of the plasma protein encoded by the< em> obese gene. JL Halaas, KS Gajiwala, M Maffei, SL Cohen Science, 1995 Link: https://scholar.google.com/citations?viewop=viewcitation&hl=en&user=7MuXtUgAAAAJ&citationforview=7MuXtUgAAAAJ:L7CI7m0gUJcC