doi.bio/w_a_hendrickson
W.A. Hendrickson
Wayne Hendrickson is a researcher in the field of Macromolecular structure and X-ray crystallography. He is based at Columbia University in the Department of Biological Sciences.
Research Overview
Hendrickson's research focuses on macromolecular structure and aims to develop an in-depth understanding of biological activity. His laboratory primarily uses diffraction analysis as a research tool, alongside theory and other physical and biochemical methods of analysis. The program covers three broad themes: structural biology of specific systems, methodology development, and biophysical principles of conformation, dynamics, and assembly.
The macromolecules under study often relate to the following biological subjects:
- Cell surface interactions and signal transduction
- Immune response interactions
- Cellular responses to stress
- Genetic replication and transcription
- Carbohydrate recognition
- Oxygen transport
Notable Publications
- Peat, T.S., Frank, E.G., McDonald, J.P., Levine, A.S., Woodgate, R. and Hendrickson, W.A. (1996). Structure of the UmuD' protein and its regulation in response to DNA damage. Nature 380, 727-730.
- Fremont, D.H., Hendrickson, W.A., Marrack, P. and Kappler, J. (1996). Structures of an MHC class II molecule with covalently bound single peptides. Science 272, 1001-1004.
- Lima, C.D., Klein, M.G., Weinstein, I.B. and Hendrickson, W.A. (1996). Three-dimensional structure of human protein kinase C interacting protein 1, a member of the HIT family of proteins. Proc. Natl. Acad. Sci. USA 93, 5357-5362.
- Zhu, X., Zhao, X., Burkholder, W.F., Gragerov, A., Ogata, C., Gottesman, M.E. and Hendrickson W.A. (1996). Structural analysis of substrate binding by the molecular chaperone DnaK. Science 272, 1605-1614.
- Shapiro, L., Doyle, J.P., Hensley, P., Colman, D.R. and Hendrickson, W.A. (1996). Crystal structure of the extracellular domain from Po, the major structural protein of peripheral nerve myelin. Neuron 17, 435-449.
- Yamaguchi, H. and Hendrickson W.A. (1996). Structural basis for activation of the lymphocyte kinase Lck upon tyrosine phosphorylation. Nature 384, 484-489.
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